Dataset Information


Transcription profiling by array of HT29 colon carcinoma cells overexpressing mitochondrial aconitase ACO2

ABSTRACT: Our previous proteomics analysis suggested down-regulation of mitochondrial aconitase (ACO2) plays an important role in colorectal cancer. To evaluate the effect of mitochondrial aconitase overexpression on the metabolic and signaling pathway changes in colon cancer cell line HT29, we generated two ACO2 overexpressing cell lines #C and #UD and the mock-transfected vector control #VE. HT29 colon cancer cells overexpressing ACO2 exhibited lower rate of cell proliferation in vitro and reduced tumor growth potential in nude mice. In order to understand the signaling pathway changes, cDNA microarray analysis using GeneChips from Affymetrix were carried out.


ORGANISM(S): Homo sapiens  

PROVIDER: E-MEXP-1996 | ExpressionAtlas | 2015-10-22

REPOSITORIES: ExpressionAtlas

Similar Datasets

2010-01-14 | E-MEXP-1996 | ArrayExpress
2011-07-01 | E-GEOD-29760 | ArrayExpress
2011-05-04 | E-MEXP-2743 | ArrayExpress
2014-06-03 | E-GEOD-56857 | ArrayExpress
2019-06-11 | E-MTAB-7791 | ArrayExpress
2012-09-28 | E-MEXP-3595 | ArrayExpress
2016-02-08 | PXD002425 | Pride
2008-04-30 | E-GEOD-10455 | ArrayExpress
2012-07-01 | E-MEXP-3479 | ArrayExpress
2014-09-18 | E-GEOD-51087 | ArrayExpress