Transcriptomics

Dataset Information

120

Transcription profiling by array of HT29 colon carcinoma cells overexpressing mitochondrial aconitase ACO2


ABSTRACT: Our previous proteomics analysis suggested down-regulation of mitochondrial aconitase (ACO2) plays an important role in colorectal cancer. To evaluate the effect of mitochondrial aconitase overexpression on the metabolic and signaling pathway changes in colon cancer cell line HT29, we generated two ACO2 overexpressing cell lines #C and #UD and the mock-transfected vector control #VE. HT29 colon cancer cells overexpressing ACO2 exhibited lower rate of cell proliferation in vitro and reduced tumor growth potential in nude mice. In order to understand the signaling pathway changes, cDNA microarray analysis using GeneChips from Affymetrix were carried out.

REANALYSIS of: E-MEXP-1996

ORGANISM(S): Homo sapiens  

PROVIDER: E-MEXP-1996 | ExpressionAtlas | 2015-10-22

REPOSITORIES: ExpressionAtlas

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