Transcriptomics,Multiomics

Dataset Information

125

Transcription profiling by array of paired tumour and normal samples from colorectal cancer patients


ABSTRACT: We investigate the relevance of RNA integrity in gene expression analysis as well as analysis methods to accommodate the possible effects of degradation using paired tumour and normal samples from colorectal cancer patients undergoing colonic resection.

REANALYSIS of: E-MEXP-3715

ORGANISM(S): Homo sapiens  

PROVIDER: E-MEXP-3715 | ExpressionAtlas | 2015-10-22

REPOSITORIES: ExpressionAtlas

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Publications

Quality assessment and data handling methods for Affymetrix Gene 1.0 ST arrays with variable RNA integrity.

Viljoen Katie S KS   Blackburn Jonathan M JM  

BMC genomics 20130116


BACKGROUND: RNA and microarray quality assessment form an integral part of gene expression analysis and, although methods such as the RNA integrity number (RIN) algorithm reliably asses RNA integrity, the relevance of RNA integrity in gene expression analysis as well as analysis methods to accommodate the possible effects of degradation requires further investigation. We investigated the relationship between RNA integrity and array quality on the commonly used Affymetrix Gene 1.0 ST array platfo  ...[more]

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