Dataset Information


Transcriptional profiling by array of intestinal epithelial cells from foetal and paediatric gut

ABSTRACT: CD326+ sorted intestinal epithelial cells from foetal (9-12 wk gestational age) small bowel and large bowel, CD326+ sorted intestinal epithelial cells from mucosal biopsies of paediatric (5-15 years of age) terminal illeum, ascending colon and sigmoid colon FPG=Foetal proximal gut, FDG=Foetal distal gut, PTI=paediatric terminal ileum, PAC=paedaitric ascending colon, PSC=paediatric sigmoid colon


ORGANISM(S): Homo sapiens  

PROVIDER: E-MTAB-3704 | ExpressionAtlas | 2015-07-14

REPOSITORIES: ExpressionAtlas

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Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease.

Kraiczy J J   Nayak K K   Ross A A   Raine T T   Mak T N TN   Gasparetto M M   Cario E E   Rakyan V V   Heuschkel R R   Zilbauer M M  

Mucosal immunology 20150916 3

DNA methylation is one of the major epigenetic mechanisms implicated in regulating cellular development and cell-type-specific gene expression. Here we performed simultaneous genome-wide DNA methylation and gene expression analysis on purified intestinal epithelial cells derived from human fetal gut, healthy pediatric biopsies, and children newly diagnosed with inflammatory bowel disease (IBD). Results were validated using pyrosequencing, real-time PCR, and immunostaining. The functional impact  ...[more]

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