Transcriptomics

Dataset Information

0

RNA-sequencing of Aire-ILC3 cells from wild-type and Aire-deficient mice


ABSTRACT: Autoimmune regulator (Aire) plays an indispensable role in the induction of central immune tolerance. We identify a novel subset of Rorγt-dependent innate lymphoid cell-type in secondary lymphoid organs, which presents endogenously generated antigens and contributes to peripheral T cell tolerance. In this experiment, transcriptomes of these Aire-ILC3 cells are characterized in wild-type Balb/C and Aire-/- Balb/C mice [Ramsey, C. et al. (2002) Hum Mol Genet 11:397-409] using RNA-seq method. To obtain the cells, peripheral lymph nodes were minced, enzymatically digested, and Aire-ILC3 cells were FACS-sorted as Lin-, MHCII+, CD80+, IL7Ra+ cells.

REANALYSIS of: E-MTAB-7088

ORGANISM(S): Mus musculus  

PROVIDER: E-MTAB-7088 | ExpressionAtlas | 2019-01-16

REPOSITORIES: ExpressionAtlas

Similar Datasets

2019-03-14 | E-MTAB-7088 | ArrayExpress
| GSE74257 | GEO
2015-10-23 | E-GEOD-74257 | ArrayExpress
2008-08-08 | GSE12388 | GEO
2015-12-31 | E-MTAB-3879 | ArrayExpress
2016-06-27 | E-MTAB-4596 | ArrayExpress
2012-08-11 | E-MEXP-3343 | ArrayExpress
2013-06-28 | E-MEXP-3665 | ArrayExpress
2015-05-19 | E-GEOD-65617 | ArrayExpress
2020-01-14 | E-MTAB-8255 | ArrayExpress