Source Images A multispectral 3D live organoid imaging platform to screen probes for fluorescence guided surgery

ABSTRACT: Achieving complete tumor resection is challenging and can be improved by real-time fluorescence guided surgery with molecular-targeted probes. However, pre-clinical identification and validation of probes presents a lengthy process that is traditionally performed in animal models and hampered by inter- and intra-tumoral heterogeneity in target expression. To screen multiple probes at patient scale, we developed a multispectral real-time 3D imaging platform that implements organoid technology to effectively model patient tumor heterogeneity and, importantly, healthy human tissue binding.

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PROVIDER: S-BIAD1119 | bioimages |

REPOSITORIES: bioimages