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High-Parameter Spatial Profiling of the Pancreas in Human Type 1 Diabetes

ABSTRACT: In autoimmune Type 1 diabetes (T1D), immune cells progressively infiltrate and destroy the islets of Langerhans – islands of endocrine tissue dispersed throughout the pancreas. However, it is unclear how this process, called ‘insulitis’, develops and progresses within this organ. Here, using highly multiplexed CO-Detection by indEXing (CODEX) tissue imaging and cadaveric pancreas samples from autoantibody positive, T1D, and non-diabetic donors, we examine pseudotemporal-spatial patterns of insulitis and exocrine inflammation within large pancreatic tissue sections.

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PROVIDER: S-BIAD859 | bioimages |

REPOSITORIES: bioimages

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