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ABSTRACT: The model reproduces the plots in Figures 1 and 2. Note that the units of the time scale "A" are not right in the paper, it was corrected by the curator. Model successfully tested on MathSBML.

SUBMITTER: Harish Dharuri  

PROVIDER: BIOMD0000000202 | BioModels | 2008-11-24


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A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.

De Young G W GW   Keizer J J  

Proceedings of the National Academy of Sciences of the United States of America 19921001 20

Relying on quantitative measurements of Ca2+ activation and inhibition of the inositol 1,4,5-trisphosphate (IP3) receptor in the endoplasmic reticulum, we construct a simplified kinetic model to describe the properties of this channel. Selecting rate constants to fit key kinetic and equilibrium data, we find that the model reproduces a variety of in vivo and in vitro experiments. In combination with Ca(2+)-ATPase activity for Ca2+ uptake into the endoplasmic reticulum, the model leads to cytopla  ...[more]

Publication: 1/2

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