Ontology highlight
ABSTRACT:
REANALYSIS of: BIOMD0000000019BIOMD0000000049BIOMD0000000048
REANALYSED by: BIOMD0000000453BIOMD0000000452
SUBMITTER: Harish Dharuri
PROVIDER: BIOMD0000000205 | BioModels | 2008-11-27
REPOSITORIES: BioModels
Ung Choong Yong CY Li Hu H Ma Xiao Hua XH Jia Jia J Li Bao Wen BW Low Boon Chuan BC Chen Yu Zong YZ
FEBS letters 20080527 15
Deregulations of EGFR endocytosis in EGFR-ERK signaling are known to cause cancers and developmental disorders. Mutations that impaired c-Cbl-EGFR association delay EGFR endocytosis and produce higher mitogenic signals in lung cancer. ROCK, an effector of small GTPase RhoA was shown to negatively regulate EGFR endocytosis via endophilin A1. A mathematical model was developed to study how RhoA and ROCK regulate EGFR endocytosis. Our study suggested that over-expressing RhoA as well as ROCK prolon ...[more]