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Ung2008_EGFR_Endocytosis


ABSTRACT: Model reproduces the various plots in the publication for "Control" concentrations. Model successfully tested on MathSBML.

SUBMITTER: Harish Dharuri  

PROVIDER: BIOMD0000000205 | BioModels | 2008-11-27

REPOSITORIES: BioModels

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Publications

Simulation of the regulation of EGFR endocytosis and EGFR-ERK signaling by endophilin-mediated RhoA-EGFR crosstalk.

Ung Choong Yong CY   Li Hu H   Ma Xiao Hua XH   Jia Jia J   Li Bao Wen BW   Low Boon Chuan BC   Chen Yu Zong YZ  

FEBS letters 20080527 15


Deregulations of EGFR endocytosis in EGFR-ERK signaling are known to cause cancers and developmental disorders. Mutations that impaired c-Cbl-EGFR association delay EGFR endocytosis and produce higher mitogenic signals in lung cancer. ROCK, an effector of small GTPase RhoA was shown to negatively regulate EGFR endocytosis via endophilin A1. A mathematical model was developed to study how RhoA and ROCK regulate EGFR endocytosis. Our study suggested that over-expressing RhoA as well as ROCK prolon  ...[more]

Publication: 1/4

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