Ung2008_EGFR_Endocytosis
Ontology highlight
ABSTRACT:
REANALYSIS of: BIOMD0000000019BIOMD0000000049BIOMD0000000048
REANALYSED by: BIOMD0000000453BIOMD0000000452
SUBMITTER: 
Harish Dharuri
PROVIDER: BIOMD0000000205 | BioModels | 2008-11-27
REPOSITORIES: BioModels
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Publications
Simulation of the regulation of EGFR endocytosis and EGFR-ERK signaling by endophilin-mediated RhoA-EGFR crosstalk.
Ung Choong Yong CY Li Hu H Ma Xiao Hua XH Jia Jia J Li Bao Wen BW Low Boon Chuan BC Chen Yu Zong YZ
FEBS letters 20080527 15
Deregulations of EGFR endocytosis in EGFR-ERK signaling are known to cause cancers and developmental disorders. Mutations that impaired c-Cbl-EGFR association delay EGFR endocytosis and produce higher mitogenic signals in lung cancer. ROCK, an effector of small GTPase RhoA was shown to negatively regulate EGFR endocytosis via endophilin A1. A mathematical model was developed to study how RhoA and ROCK regulate EGFR endocytosis. Our study suggested that over-expressing RhoA as well as ROCK prolon ...[more]
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Project description:Model reproduces the various plots in Figure 6 and 7 of the paper. It was successfully tested on MathSBML.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
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