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Bravo2012 - Modelling blood coagulation factor Va inactivation by APC


ABSTRACT: Mathematical model of blood coagulation factor Va and Va fragment inactivation by APC, reactions with Xa and prothrombinase-prothrombin complex formation.

SUBMITTER: Krishna Kumar Tiwari  

PROVIDER: BIOMD0000000739 | BioModels | 2019-07-01

REPOSITORIES: BioModels

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Modeling of human factor Va inactivation by activated protein C.

Bravo Maria Cristina MC   Orfeo Thomas T   Mann Kenneth G KG   Everse Stephen J SJ  

BMC systems biology 20120520


Because understanding of the inventory, connectivity and dynamics of the components characterizing the process of coagulation is relatively mature, it has become an attractive target for physiochemical modeling. Such models can potentially improve the design of therapeutics. The prothrombinase complex (composed of the protease factor (F)Xa and its cofactor FVa) plays a central role in this network as the main producer of thrombin, which catalyses both the activation of platelets and the conversi  ...[more]

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