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Simon2019 - NIK-dependent p100 processing into p52, Michaelis-Menten, SBML 2v4

ABSTRACT: This model represents NIK-dependent p100 processing into p52 with Michaelis-Menten kinetics. While this model shows identical dose-response to the mass action representation, when IkBd degradation is included the dose-response is no-longer monotonic in mass action models due to substrate complex competition.

SUBMITTER: Simon Mitchell

PROVIDER: BIOMD0000000866 | BioModels | 2020-01-09

REPOSITORIES: BioModels

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Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB.

Mitchell Simon S Hoffmann Alexander A

Proceedings of the National Academy of Sciences of the United States of America 20190502 21

Signaling pathways often share molecular components, tying the activity of one pathway to the functioning of another. In the NFκB signaling system, distinct kinases mediate inflammatory and developmental signaling via RelA and RelB, respectively. Although the substrates of the developmental, so-called noncanonical, pathway are induced by inflammatory/canonical signaling, crosstalk is limited. Through dynamical systems modeling, we identified the underlying regulatory mechanism. We found that as ...[more]

PMID: 31048505

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Simon2019 - NIK-dependent p100 processing into p52, Mass Action, SBML 2v4

Project description:This model represents NIK-dependent p100 processing into p52 with mass action kinetics. While this model shows identical dose-response to the Michaelis-Menten representation, when IkBd degradation is included the dose-response is no longer monotonic in mass action models due to substrate complex competition.

2020-01-03 | BIOMD0000000868 | BioModels

Simon2019 - NIK-dependent p100 processing into p52 and IkBd degradation, mass action, SBML 2v4

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NIK-dependent p100 processing into p52 with RelB binding and IkBd degradation, mass action, SBML 2v4

Project description:This model represents NIK-dependent p100 processing into p52 followed by binding to RelB and NIK-dependent IkBd degradation. This model assesses the impact of substrate complex competition on RelB-p52.

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Project description:Rhodococcus sp. p52 Genome sequencing

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p52 transgenic expression with or without LPS in mouse lungs

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