Dataset Information

Dikicioglu2018 - Genome-scale metabolic model of Saccharomyces cerevisiae including comprehensive iron metabolism network

ABSTRACT: This SBML representation of the yeast metabolic network is made available under the Creative Commons Attribution-Share Alike 3.0 Unported Licence (see www.creativecommons.org).

SUBMITTER: Duygu Dikicioglu

PROVIDER: MODEL1709260000 | BioModels | 2019-01-16

REPOSITORIES: BioModels

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			Action	DRS
	MODEL1709260000?filename=MODEL1709260000-biopax2.owl	Owl
	MODEL1709260000?filename=MODEL1709260000-biopax3.owl	Owl
	MODEL1709260000?filename=MODEL1709260000.cellml	Other
	MODEL1709260000?filename=MODEL1709260000.m	Other
	MODEL1709260000?filename=MODEL1709260000.sci	Other

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Extension of the yeast metabolic model to include iron metabolism and its use to estimate global levels of iron-recruiting enzyme abundance from cofactor requirements.

Dikicioglu Duygu D Oliver Stephen G SG

Biotechnology and bioengineering 20190112 3

Metabolic networks adapt to changes in their environment by modulating the activity of their enzymes and transporters; often by changing their abundance. Understanding such quantitative changes can shed light onto how metabolic adaptation works, or how it can fail and lead to a metabolically dysfunctional state. We propose a strategy to quantify metabolic protein requirements for cofactor-utilising enzymes and transporters through constraint-based modelling. The first eukaryotic genome-scale met ...[more]

PMID: 30578666

Publication: 1/403

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