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Pereira2018 - Genome-scale metabolic model for Actinobacillus succinogenes 130Z


ABSTRACT: The model, iBP722, was reconstructed based on the functional reannotation of the complete genome sequence of A. succinogenes 130Z and manual inspection of metabolic pathways, covering 1072 enzymatic reactions associated with 722 metabolic genes that involve 713 metabolites. The highly curated model was effective in capturing the growth of A. succinogenes on various carbon sources, as well as the SA production under various growth conditions with fair agreement between experimental and predicted data. Calculated flux distributions under different conditions show that a number of metabolic pathways are affected by the activity of some metabolic enzymes at key nodes in metabolism, including the transport mechanism of carbon sources and the ability to fix carbon dioxide.

SUBMITTER: Sónia  

PROVIDER: MODEL1804130001 | BioModels | 2019-05-16

REPOSITORIES: BioModels

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