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Susree2018 - Effect of coated platelets on thrombin generation


ABSTRACT: Mathematical model of blood coagulation that simulates the effect of coated platelets on thrombin generation.

SUBMITTER: Matthew Roberts  

PROVIDER: MODEL1808080001 | BioModels | 2018-08-08

REPOSITORIES: BioModels

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Publications

Coated platelets introduce significant delay in onset of peak thrombin production: Theoretical predictions.

Susree M M   Panteleev Mikhail A MA   Anand M M  

Journal of theoretical biology 20180518


Platelets play a crucial role in the initiation, progress, termination as well as regulation of blood coagulation. Recent studies have confirmed that not all but only a small percentage of thrombin-activated platelets ("coated" platelets) exhibit procoagulant properties (namely the expression of phosphatidylserine binding sites) required for the acceleration and progress of coagulation. A mechanistic model is developed for in vitro coagulation whose key features are distinct equations for coated  ...[more]

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