Ontology highlight
ABSTRACT:
SUBMITTER: Matthew Roberts
PROVIDER: MODEL1807240002 | BioModels | 2018-07-24
REPOSITORIES: BioModels
Willems G M GM Lindhout T T Hermens W T WT Hemker H C HC
Haemostasis 19910101 4
A simulation model for the production of thrombin in plasma is presented. Values of the reaction rate constants as determined in purified systems are used and the model is tested by comparison of simulations of factor Xa, factor Va and thrombin generation curves with experimental data obtained in thromboplastin-activated plasma. Simulations of the effect of hirudin indicate that factor V is predominantly activated by thrombin and not by factor Xa. The model predicts a threshold value for the fac ...[more]