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Louzoun2014 - A mathematical model for pancreatic cancer growth and treatments


ABSTRACT: This is a mathematical model of pancreatic cancer, geared towards examining the efficacy of tumor-suppressing drugs in tandem with an immune response.

SUBMITTER: Johannes Meyer  

PROVIDER: MODEL1909100002 | BioModels | 2019-09-10

REPOSITORIES: BioModels

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A mathematical model for pancreatic cancer growth and treatments.

Louzoun Yoram Y   Xue Chuan C   Lesinski Gregory B GB   Friedman Avner A  

Journal of theoretical biology 20140301


Pancreatic cancer is one of the most deadly types of cancer and has extremely poor prognosis. This malignancy typically induces only limited cellular immune responses, the magnitude of which can increase with the number of encountered cancer cells. On the other hand, pancreatic cancer is highly effective at evading immune responses by inducing polarization of pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages, and promoting expansion of myeloid derived suppressor cells, which  ...[more]

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