Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mullinax2016 - Mathematical model of tumor-immune cell interactions to optimize the meta-phenotype of TIL subpopulations

ABSTRACT: This model is described in the publication: John Mullinax, Cliona O’Farrelly, Jacob G. Scott, Andreas Buttenschön, Asmaa E. Elkenawi, Fadoua El Moustaid, Alexander G. Fletcher, Clemens Grassberger, Eunjung Kim, Andriy Marusyk, Harry L.O. McClelland, Daria Miroshnychenko, Daniel Nichol. "Harnessing the lymphocyte meta-phenotype to optimize adoptive cell therapy". bioRxiv 085910; doi: 10.1101/085910 Curation Comment: Figure 4 could not be reproduced. Attempted changing parameter values for Fig. 4(D) simulation, but plots were still not exact match for all species.

DISEASE(S): Sarcoma

SUBMITTER: Emilia Chen

PROVIDER: MODEL2109110006 | BioModels | 2021-09-11

REPOSITORIES: BioModels

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	MODEL2109110006?filename=Mullinax2016.cps	Other
	MODEL2109110006?filename=Mullinax2016.xml	Xml

Items per page:

1 - 2 of 2

Similar Datasets

Evolution of conserved noncoding sequences (CNS) in Arabidopsis thaliana

Project description:We report ATAC-seq for several A. thaliana accessions in healthy leaf tissue. As part of an investigation into the evolution of conserved noncoding sequences, our goal was to identify overlaps between regions of accessible chromatin and CNS. Manuscript in review. Biorxiv preprint doi: https://doi.org/10.1101/727669

2021-01-04 | GSE164159 | GEO

Characterization of WDR5 WIN-site Inhibition in Two Glioblastoma Cancer Stem Cell Models using Bulk RNAseq

Project description:WDR5 inhibitors have been implicated as a therapeutic vulnerability in glioblastoma cancer stem cells (CSCs). We tested the transcriptional effects of two different WDR5 WIN-site inhibitors, the dihydroisoquinoline C16 and the triazole C3TD078, in two CSC models (L0 and DI318) by bulk RNAseq.These data are associated with Coker et al., "Development and Characterization of Triazole-Based WDR5 Inhibitors for the Treatment of Glioblastoma," bioRxiv, 2025, https://doi.org/10.1101/2025.07.29.667410.

2025-08-15 | GSE304999 | GEO

Transcription profiling of human peripheral blood mononuclear cells before and after exercise

Project description:Analysis of peripheral blood mononuclear cells (PBMCs) separated from whole blood of healthy male subjects; - prior to onset of exercise; - immediately following the end of exercise and; - immediately following 1 hour of recovery from exercise. To reduce individual variation and other confounding events, such as spontaneous up- and downregulation of genes, the 15 subjects in this study were pooled into 5 groups of 3 subjects each. The pools were not randomized; rather, we attempted to match the mean lymphocyte response to exercise across the five groups.

2007-07-21 | E-GEOD-1140 | biostudies-arrayexpress

Single-cell RNAseq of differentiating human iPSCs during endothelial-to-hematopoietic transition with targeted CRISPR activation

Project description:This dataset contains single cell RNAseq of human iPSCs undergoing cytokine-mediated differentiation alongside targeted CRISPR-mediated endogenous gene activation. For this experiment we sequenced single cells at day 10 of the differentiation protocol, when the cells undergo the endothelial-to-hematopoietic transition described in the paper Petazzi et al, BiorXiv DOI 10.1101/2022.10.04.510611 The dataset contains four libraries: (1) iSAM line infected with non-targeting guide RNA, (2) iSAM line infected with non-targeting guide RNA treated with Dox, (3) iSAM line infected with targeting guide RNAs library, (4) iSAM line infected with targeting guide RNAs library treated with Dox

2024-03-21 | E-MTAB-12748 | biostudies-arrayexpress

Homo sapiens

Project description:Gene expression levels with various artificial mutations -- exact match

| PRJNA154625 | ENA

Transcriptional profiling of pax2a-Low and pax2a-High thyroid follicular cells in zebrafish

Project description:Thyroid follicular cells (TFCs) are responsible for generation, storage and release of thyroid hormone. Single-cell analysis of zebrafish thyroid gland demonstrated transcriptional heterogeneity within the TFC population (Gillotay et al., bioRxiv, 2020. doi: 10.1101/2020.01.13.891630. GEO dataset for single-cell RNA-Seq.: GSE133466). Particularly, TFC displayed transcriptional heterogeneity in the expression of pax2a, a transcription factor involved in differentiation and maturation of TFCs. To validate the genetic heterogeneity, we generated a pax2a knock-in line, in which mKO2 expression is driven by endogenous pax2a locus. Using Tg(tg:nls-EGFP); pax2a:mKO2-Knock-in, we sorted for TFCs (GFP+) and separated the pax2a-Low (mKO2-Low) and pax2a-High (mKO2-High) populations for NGS.

2020-06-25 | GSE153197 | GEO

Discovery of lydiamycin A biosynthetic gene cluster in the plant pathogen Rhodococcus fascians guides structural revision and identification of molecular target

Project description:Data used for molecular networking in study of lydiamycin from Rhodococcus fascians (bioRxiv DOI: 10.1101/2024.11.13.623425)

2025-04-27 | MSV000097741 | MassIVE

Comprehensive peptide quantification for data independent acquisition mass spectrometry using chromatogram libraries

Project description:Raw DDA and DIA data to support Searle et al. 2018. Comprehensive peptide quantification for data independent acquisition mass spectrometry using chromatogram libraries. bioRxiv doi:10.1101/277822

2018-08-08 | MSV000082805 | MassIVE

Covalent Protein Painting on Cancer Cell Lines

Project description:Cancer cells were labeled with Covalent Protein Painting and resulting peptides analyzed by mass spectrometry. For further information, please see: bioRxiv 2020.01.31.929117; doi: https://doi.org/10.1101/2020.01.31.929117

2020-02-28 | MSV000085034 | MassIVE

Adoptively transferred in vitro-generated MDSCs improve T cell function and antigen-specific immunity after blunt chest trauma-induced lung injury

Project description:Does the adoptive transfer of MDSCs modulate lymphocyte (T cell) functions? Microarray expression analysis of T cells from MDSC-treated mice after Blunt chest trauma (TxT)

2022-06-16 | GSE188171 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data