Transcription profiling of human MSK-Leuk1 cells (a cellular model of oral leukoplakia) after tobacco smoke exposure to

ABSTRACT: In addition to being causally linked to the formation of multiple tumor types, tobacco use has been associated with decreased anticancer treatment efficacy and reduced survival time. A detailed understanding of the cellular mechanisms that are affected by tobacco smoke should facilitate the development of improved preventive and therapeutic strategies. We have investigated the effects of a tobacco smoke (TS) extract on the transcriptome of MSK-Leuk1 cells, a cellular model of oral leukoplakia. Using Affymetrix HGU133 Plus 2 arrays, 411 differentially expressed probesets were identified. The observed transcriptome changes were grouped according to functional information, and translated into molecular interaction network maps and signaling pathways. Pathways related to cellular proliferatio

ORGANISM(S): Homo sapiens

SUBMITTER: Piali Mukherjee 

PROVIDER: E-GEOD-10063 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress