Transcription profiling of Drosophila model of mitochondrial disease

ABSTRACT: Background: A point mutation in the Drosophila gene technical knockout (tko), encoding mitoribosomal protein S12, provokes a phenotype of respiratory chain deficiency, developmental delay and neurological abnormalities similar to those presented in many human mitochondrial disorders, as well as defective courtship behaviour. Results: Transcriptome-wide analysis of gene expression in tko25t mutant flies revealed systematic, compensatory changes in expression of genes connected with metabolism, including upregulation of lactate dehydrogenase and of many genes involved in the catabolism of fats and proteins, the TCA cycle and anaplerotic pathways feeding into it. Gut-specific enzymes involved in the primary mobilization of dietary fat and protein, as well as a number of transport functions,

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Daniel Jose Moreno Fernandez-Ayala 

PROVIDER: E-GEOD-10169 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress