IPC knockout, 14 day old female flies, 48h yeast feeding

ABSTRACT: Background Insulin signaling pathway is conserved from worms to humans. In Drosophila, three insulin-like peptides (dilps) are expressed in the insulin producing cells (IPCs) in the brain. In order to identify target genes of insulin signaling, the IPCs of female flies were destroyed during development by expressing apoptosis inducing factors reaper and head involution defective under control of the promoter region of dilp3. These insulin-deficient flies were analysed using high density microarrays. Results From the genes that appeared to be regulated in the absence of IPCs, the strongest difference was found for a gene involved in carbohydrate metabolism. Sequence analysis revealed that it is an alpha-glucosidase, which is able to break down disaccharides and/or glycogen. Conclusions W

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Matthias Bauer 

PROVIDER: E-GEOD-10625 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress