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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Histone H3 K4,36,79G

ABSTRACT: Total RNA from two replicate cultures of wild-type and mutant strains was isolated and the expression profiles were determined using Affymetrix arrays. Comparisons between the sample groups allow the identification of genes regulated by histone H3 K4,36,79G mutant. Keywords: repeat Comparison of genes whose mRNA levels are affected in a histone H3 K4,36,79G mutant yeast strain compared to wild-type yeast strain.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: John Wyrick

PROVIDER: E-GEOD-10930 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genetic and genomewide analysis of simultaneous mutations in acetylated and methylated lysine residues in histone H3 in Saccharomyces cerevisiae.

Jin Yi Y Rodriguez Amy M AM Wyrick John J JJ

Genetics 20081215 2

Acetylated and methylated lysine residues in histone H3 play important roles in regulating yeast gene expression and other cellular processes. Previous studies have suggested that histone H3 acetylated and methylated lysine residues may functionally interact through interdependent pathways to regulate gene transcription. A common genetic test for functional interdependence is to characterize the phenotype of a double mutant. Using this strategy, we tested the genetic interaction between histone ...[more]

PMID: 19087956

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