Transcription profiling of mouse GATA4 conditional knockout small intestine

ABSTRACT: Background and Aims: Although the zinc finger transcription factor GATA4 has been implicated in regulating jejunal gene expression, the contribution of GATA4 in controlling jejunal physiology has not been addressed. Methods: We generated mice in which the Gata4 gene was specifically deleted in the small intestinal epithelium. Measurements of plasma cholesterol and phospholipids, intestinal absorption of dietary fat and cholesterol, and gene expression were performed on these animals. Results: Mice lacking GATA4 in the intestine displayed a dramatic block in their ability to absorb cholesterol and dietary fat. Comparison of the global gene expression profiles of control jejunum, control ileum, and GATA4 null jejunum by gene array analysis demonstrated that GATA4 null jejunum lost expressio

ORGANISM(S): Mus musculus

SUBMITTER: Stephen Duncan 

PROVIDER: E-GEOD-11194 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress