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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Rb knockout retinal explant comparison

ABSTRACT: knockout and wildtype sample pair Keywords = rod Keywords = retina Keywords = mouse Keywords = Rb

ORGANISM(S): Mus musculus

SUBMITTER: Michael Dyer

PROVIDER: E-GEOD-1129 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Rb regulates proliferation and rod photoreceptor development in the mouse retina.

Zhang Jiakun J Gray Jonathan J Wu Lizhao L Leone Gustavo G Rowan Sheldon S Cepko Constance L CL Zhu Xuemei X Craft Cheryl M CM Dyer Michael A MA

Nature genetics 20040229 4

The retinoblastoma protein (Rb) regulates proliferation, cell fate specification and differentiation in the developing central nervous system (CNS), but the role of Rb in the developing mouse retina has not been studied, because Rb-deficient embryos die before the retinas are fully formed. We combined several genetic approaches to explore the role of Rb in the mouse retina. During postnatal development, Rb is expressed in proliferating retinal progenitor cells and differentiating rod photorecept ...[more]

PMID: 14991054

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Rb knockout retinal explant comparison

Project description:knockout and wildtype sample pair Keywords = rod Keywords = retina Keywords = mouse Keywords = Rb Keywords: other

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