MPA and NQO studies (Sevilla)
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Antonio Casamayor
PROVIDER: E-GEOD-11561 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair.
Gaillard Hélène H Tous Cristina C Botet Javier J González-Aguilera Cristina C Quintero Maria José MJ Viladevall Laia L García-Rubio María L ML Rodríguez-Gil Alfonso A Marín Antonio A Ariño Joaquín J Revuelta José Luis JL Chávez Sebastián S Aguilera Andrés A
PLoS genetics 20090206 2
RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for transcription resumption. One important type of hindrance consists of DNA lesions, which are removed by transcription-coupled repair (TC-NER), a specific sub-pathway of nucleotide excision repair. To improve our knowledge of transcription elongation and its coupling to TC-NER, we used the yeast library of non-essential knock-out mutations to screen for genes conferring resistanc ...[more]
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