Transcription profiling of zebrafish embryos reveals AHR Activation by TCDD Downregulates Sox9b expression producing jaw malformation

ABSTRACT: Exposure to environmental contaminants can disrupt normal development of the early vertebrate skeleton. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) impairs craniofacial skeletal development across many vertebrate species and its effects are especially prominent in early life stages of fish. TCDD activates the aryl hydrocarbon receptor (AHR), a transcription factor that mediates most if not all TCDD responses. We investigated the transcriptional response in the developing zebrafish jaw following TCDD exposure using DNA microarrays. Zebrafish larvae were exposed to TCDD at 96 h postfertilization (hpf) and jaw cartilage tissue was harvested for microarray analysis at 1, 2, 4 and 12 h postexposure (hpe). Numerous chondrogenic transcripts were misregulated by TCDD in the jaw. Comparison of

ORGANISM(S): Danio rerio

SUBMITTER: Kong Xiong 

PROVIDER: E-GEOD-11893 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress