DNA profiling of serous ovarian and Fallopian tube carcinomas with array CGH and MLPA

ABSTRACT: Primary serous ovarian carcinoma (OVCA) and serous Fallopian tube carcinoma (FTC), both belonging to the BRCA-linked tumour spectrum, share many properties and are treated similarly. However, a detailed molecular comparison has been lacking. We hypothesized that comparative genomic studies of serous OVCAs and FTCs should point to gene regions critically involved in their tumorigenesis. Array comparative genomic hybridization (array CGH) analysis indicated that serous OVCAs and serous FTCs displayed common but also more distinctive patterns of recurrent changes. Targeted gene identification using a dedicated multiplex ligation-dependent probe amplification (MLPA) probe set directly identified EIF2C2 on 8q as a potentially important driver gene. Other previously unappreciated gained/amplifie

ORGANISM(S): Homo sapiens

SUBMITTER: Marlies Nowee 

PROVIDER: E-GEOD-12040 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress