Transcription profiling of rat mammary gland development after exposure to dietary soy protein

ABSTRACT: The linkage between nutrition and cancer prevention is an intriguing concept that is gaining widespread support based on epidemiological and animal studies. Multiple mechanisms likely underlie dietary protection against cancer, with effects influenced by target tissue response, cell-cell interactions and developmental context. Given the negative correlation between breast cancer incidence and intake of soy foods by Asian women, and the increasing consumption of soy protein-based formula by infants in the Western world, we have studied soy protein isolate (SPI) used in most infant formula as a paradigm to evaluate diet as a risk factor in a rodent model of mammary cancer. We previously demonstrated that lifetime exposure to dietary SPI reduced the incidence of N-methyl-N-nitrosourea-induced

ORGANISM(S): Rattus norvegicus

SUBMITTER: Ying Su 

PROVIDER: E-GEOD-12217 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress