Effect of microgravity on brain gene expression in mice

ABSTRACT: Changes in gravitational force such as that experienced by astronauts during space flight induce a redistribution of fluids from the caudad to the cephalad portion of the body together with an elimination of normal head-to-foot hydrostatic pressure gradients. To assess brain gene profile changes associated with microgravity and fluid shift, a large-scale analysis of mRNA expression levels was performed in the brains of 2 weeks control and hindlimb-unloaded (HU) mice using cDNA microarrays. Although to different extent, all functional categories displayed significantly regulated genes indicating that considerable transcriptomic alterations are induced by HU. Interestingly, the TIC class (transport of small molecules and ions into the cells) had the highest percentage of up-regulated genes,

ORGANISM(S): Mus musculus

SUBMITTER: Dumitru Iacobas 

PROVIDER: E-GEOD-12312 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress