Definitive haplotypes from a collection of complete hydatidiform moles (CHMs)

ABSTRACT: The haplotype map constructed by the International HapMap Project is a valuable source for the studies of disease genes, population structure, and evolution. In the Project, haplotypes have been inferred from experimentally determined genotypes, and are fairly accurate for Caucasians and Africans since the inference was based on the genotypes of trios. However, the inference for the Asians populations was less accurate, because of the lack of familial information. Here we assessed how the error in the inference can affect downstream studies, especially the analysis of recent positive selections, by comparing the results of the analyses using the data of HapMap JPT and of definitive haplotypes (DHaplo-DB) determined by us from a collection of Japanese complete hydatidiform moles (CHM), each

ORGANISM(S): Homo sapiens

SUBMITTER: Kiyoko Kato 

PROVIDER: E-GEOD-12713 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress