No-match ORESTES explored as tumor markers

ABSTRACT: Sequencing technologies together with new bioinformatics tools have led to the complete sequencing of various genomes. However, information regarding the human transcriptome and its annotation is yet to be completed. The Human Cancer Genome Project, using ORESTES (open reading frame EST sequences) methodology, contributed to this major objective by generating data from about 1.2 million expressed sequence tags (ESTs). Approximately 30% of these sequences did not align to ESTs in the public databases and were considered no-match ORESTES. On the basis that a set of these ESTs could represent new transcripts, we constructed a cDNA microarray. This platform was used to hybridize against 12 different normal or tumor tissues. We identified 3,421 transcribed regions not associated with annotated

ORGANISM(S): Homo sapiens

SUBMITTER: Barbara Mello 

PROVIDER: E-GEOD-12737 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress