HPV16 E7 expression effect on expression profile mediated by tumor necrosis factor
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Luisa Villa
PROVIDER: E-GEOD-17892 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Expression of human papillomavirus type 16 E7 oncoprotein alters keratinocytes expression profile in response to tumor necrosis factor-alpha.
Boccardo Enrique E Manzini Baldi Carina Victoria CV Carvalho Alex Fiorini AF Rabachini Tatiana T Torres César C Barreta Luiz André LA Brentani Helena H Villa Luisa Lina LL
Carcinogenesis 20091230 3
Acute expression of E7 oncogene from human papillomavirus (HPV) 16 or HPV18 is sufficient to overcome tumor necrosis factor (TNF)-alpha cytostatic effect on primary human keratinocytes. In the present study, we investigated the molecular basis of E7-induced TNF resistance through a comparative analysis of the effect of this cytokine on the proliferation and global gene expression of normal and E7-expressing keratinocytes. Using E7 functional mutants, we show that E7-induced TNF resistance correl ...[more]
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