Microarray for suspension cells of PA14 WT with and without NE (50 uM and 500 uM) for 7 h

ABSTRACT: It has been proposed that the gastro-intestinal tract environment containing high levels of neuroendocrine hormones is important for gut-derived P. aeruginosa infections. In this study, we report that the hormone norepinephrine increases P. aeruginosa PA14 growth, virulence factor production, invasion of HCT-8 epithelial cells, and swimming motility in a concentration-dependent manner. Transcriptome analysis of P. aeruginosa exposed to 500 µM, but not 50 µM, norepinephrine for 7 h showed that genes involved in the regulation of the virulence determinants pyocyanin, elastase, and Pseudomonas quinolone signal (PQS, 2-heptyl-3-hydroxy-4-quinolone) were up-regulated. The production of rhamnolipids, which are also important in P. aeruginosa infections, was significantly decreased on semi-solid

ORGANISM(S): Pseudomonas aeruginosa UCBPP-PA14

SUBMITTER: Manjunath Hegde 

PROVIDER: E-GEOD-13326 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress