Transcription profiling of Drosophila NRF-2alpha/GABPalpha homologue delg mutants versus control reveals reduced expression of multiple genes encoding mitochondrial proteins

ABSTRACT: Nuclear transcription factors drive mitochondrial mass by regulating the expression of genes encoding mitochondrial proteins. Among these factors, nuclear respiratory factor 2 (NRF-2/GABP) has been proposed to be critical for mitochondrial mass in mammalian cells, yet there is little genetic evidence to support this function in vivo. Here, we show that mutants of the Drosophila melanogaster NRF-2alpha/GABPalpha homologue Delg (CG6338) have reduced expression of multiple genes encoding mitochondrial proteins, leading to reduced mitochondrial mass. Experiment Overall Design: Six samples were analyzed in total: three biological replicates of the control (Df_plus) and three biological replicates of the mutant (Df_delg).

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Claudia Baltzer 

PROVIDER: E-GEOD-14058 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress