Microarray Analysis of Acid-Stress Induced Changes in EHEC O157:H7

ABSTRACT: While significant advances have been made in EHEC pathogenesis, we still do not fully understand the impact of environmental stress on EHEC virulence. During the course of infection, EHEC must evade or overcome several biological barriers, the first of which is the gastric acidity encountered during passage through the stomach. EHEC is remarkable in its ability to tolerate this acidity. There are four different acid resistance systems that provide E. coli O157:H7 protection against exposure to low pH (2-2.5). Interestingly, EHEC uses these acid resistance systems differentially for survival in foods versus the bovine intestinal tract. The glutamate-dependent acid-resistance system is thought to offer the best protection below pH 3. Since the infectious dose of EHEC is so low (50-100 org

ORGANISM(S): Escherichia coli

SUBMITTER: Julianne Kus 

PROVIDER: E-GEOD-14069 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress