Altered gene expression profiles in testis developmental exposed to endocrine disruptors

ABSTRACT: Environmental reproductive health focuses on the effect of exposure to contaminants considered as endocrine disruptors. Developmental testis is considered as target of these compounds affecting testicular functions in adults and suspected implications in tumor etiology. Comparative analysis of gene expression in mouse testis exposed to five disruptors, three different dosages and three accumulative developmental stages shown defined signature profiles of gene deregulation for MEHP (monoethyl phthalate) and zearalenone (a phytoestrogen) and different to 17β-estradiol exposure. The effects are even detected in postpuberal male offspring from premating exposed mothers. Oxidative stress response, protein ubiquitination and oxidative phosphorylation are the most representative pathways affected

ORGANISM(S): Mus musculus

SUBMITTER: Luis Lopez-Fernandez 

PROVIDER: E-GEOD-14774 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress