Asporin is Expressed at Higher Levels in the More Degenerate Human Intervertebral Disc Tissue

ABSTRACT: Asporin, also known as periodontal ligament-associated protein 1 (PLAP1), is a member of the family of small leucine-rich proteoglycan (SLRP) family. It is present within the cartilage extracellular matrix (ECM), and is reported have a genetic association with osteoarthritis. Its D14 allele has recently been found to be associated with lumbar disc degeneration in Asian subjects. There have been no studies, however, of this gene’s normal immunohistochemical localization within the human intervertebral disc, nor of expression levels in Caucasian individuals with disc degeneration. Studies were approved by our human subjects Institutional Review Board. Methods included immunohistochemical localization of asporin in the disc of humans and the sand rat (a small rodent with spontaneous age-re

ORGANISM(S): Homo sapiens

SUBMITTER: Helen Gruber 

PROVIDER: E-GEOD-15227 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress