Coeevolution of a transcriptional network by compensatory trans and cis mutations

ABSTRACT: Transcriptional networks have been shown to evolve very rapidly, prompting questions as to how such changes arise and are tolerated. Recent comparisons of transcriptional networks across species have implicated variations in the cis-acting DNA sequences near genes as the main cause of divergence. What is less clear is how these changes interact with trans-acting changes occurring elsewhere in the genetic circuit. Here, we report the discovery of a system of compensatory trans and cis mutations in the yeast AP-1 transcriptional network that allows for conserved transcriptional regulation despite continued genetic change. We pinpoint a single species, the fungal pathogen Candida glabrata, in which a trans mutation has occurred very recently in a single AP-1 family member distinguishing it fr

ORGANISM(S): Candida glabrata

SUBMITTER: Dwight Kuo 

PROVIDER: E-GEOD-15818 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress