Transcription profiling of mouse Naive Treg, allogeneic tumor-activated Treg, and GVHD-activated Treg cells

ABSTRACT: Regulatory T (Treg) cells play an important role in the induction and maintenance of peripheral tolerance. Treg cells also suppress a variety of other immune responses, including anti-tumor and alloimmune responses. We have previously reported that tumor-activated Treg cells express granzyme B and that granzyme B is important for Treg cell-mediated suppression of anti-tumor immune responses (GSE13409). Here, we report that allogeneic mismatch also induces the expression of granzyme B. Granzyme B-deficient mice challenged with fully mismatched allogeneic P815 mastocytoma cells have markedly improved survival compared to WT and other granzyme- or perforin-deficient mice, suggesting an immunoregulatory role for granzyme B in this setting. Treg cells harvested from the tumor environment o

ORGANISM(S): Mus musculus

SUBMITTER: Rekha Meyer 

PROVIDER: E-GEOD-16210 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress