Combinatorial targeting of glycolysis and oxidative phosphorylation suppresses tumor growth and metastases.

ABSTRACT: The Warburg effect, consisting of increased glucose uptake and glycolysis, provides metabolic energy as well as cellular building blocks for tumor growth. Inhibition of the Warburg effect with 2-deoxyglucose (2DG) has been explored in clinical trials with limited efficacy. Blockage of glycolysis can induce autopahgy resulting in alternative energy generation through oxidative phosphorylation providing a potential bypass of the effects of inhibition of glycolysis. Here in we demonstrate that activation of AMPK, as a consequence of energetic stress, induces mitochondrial energy production potentially bypassing the effects of glycolysis inhibition. We thus combined blockage of glycolysis by 2DG with inhibition of the electron transfer complex I (ETC1) in the mitochondria with the clinically a

ORGANISM(S): Homo sapiens

SUBMITTER: Sangbae Kim 

PROVIDER: E-GEOD-16816 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress