A search for small noncoding RNAs in Staphylococcus aureus reveals a conserved sequence motif for regulation.

ABSTRACT: Analysis of the intergenic regions of Staphylococcus aureus by bioinformatics predicted multiple regulatory regions. From this analysis, we also characterized 11 novel noncoding RNAs (RsaA-K) that are expressed in several S. aureus strains under different experimental conditions. Many of them accumulate in the late-exponential phase of growth. All ncRNAs are stable and their expression is Hfq-independent. The transcription of several of them is regulated by the alternative sigma factor B (RsaA, D, and F) while the expression of RsaE is agrA-dependent. Six of these ncRNAs are specific to S. aureus, four are conserved in other staphylococci, and RsaE is additionally present in Bacillaceae. Transcriptomic and proteomic analysis indicated that RsaE regulates the synthesis of proteins involved

ORGANISM(S): Staphylococcus aureus

SUBMITTER: Marie-Josée Cros 

PROVIDER: E-GEOD-17135 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress