Transcription profiling of the dynamic Innate Immune Responses in Human Bronchial Epithelial Cells against SARS-CoV and DOHV infection

ABSTRACT: Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection causes an immune-mediated disease. We have recently shown that SARS-CoV-induced epithelial Calu-3 cytokines could exacerbate and dampen host inflammatory and T cell responses, respectively, through modulating the functions of macrophages and dendritic cells, thereby suggesting that not only are lung epithelial cells the primary cells of SARS-CoV infection, but they also involve in initiating and orchestrating the host innate and adaptive immunity. Comprehensive evaluation of the complex epithelial signaling to SARS-CoV is, thus, crucial for paving the way to better understand SARS pathogenesis and develop the innovative therapeutics against SARS. Here, based on the microarray-based functional genomics, we report

ORGANISM(S): Homo sapiens

SUBMITTER: Naoko Iwata 

PROVIDER: E-GEOD-17400 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress