Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation

ABSTRACT: Background: Type I interferons (IFNs) are essential to the clearance of viral diseases, in part by initiating upregulation of IFN regulated genes (IRGs). A clear distinction between genes upregulated directly by virus and genes upregulated by secondary IFN production has not been made. Here we investigated the genes regulated by IFN-a2b compared to the genes regulated by SARS-CoV infection in ferrets. Methods: We characterized early host immune responses in peripheral blood and lung necropsies of ferrets injected with IFN-a2b or infected with SARS-CoV/Tor 2 strain, using microarray analysis on the Affymetrix platform. Results: We identified a common IRG signature that was upregulated in both SARS-CoV infected ferrets as well as in ferrets injected with IFN-a2b. We also identified unique

ORGANISM(S): Mustela putorius furo

SUBMITTER: Longsi Ran 

PROVIDER: E-GEOD-22581 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress