Transcription profiling of Dahl salt-sensitive and salt-resistant congenic rats
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Bina Joe
PROVIDER: E-GEOD-1775 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Locating a blood pressure quantitative trait locus within 117 kb on the rat genome: substitution mapping and renal expression analysis.
Garrett Michael R MR Meng Haijin H Rapp John P JP Joe Bina B
Hypertension (Dallas, Tex. : 1979) 20050117 3
Previously, a blood pressure (BP) quantitative trait locus (QTL) on rat chromosome 9 (RNO9) was localized to a <2.4 cM interval using congenic strains generated by introgressing segments of RNO9 from the Dahl salt-resistant (R) rat into the background of the Dahl salt-sensitive (S) rat. Renal gene expression using Affymetrix gene chips was profiled on S and a congenic strain spanning the 2.4-cM BP QTL interval. This analysis identified 20 differentially expressed genes/expressed sequence tags. O ...[more]
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