Expression profiling of rat MHC and NKC genes in skin explant assays reveals genes that are regulated in GVHD

ABSTRACT: Expression profiling of rat major histocompatibility complex and natural killer complex genes in skin explant assays reveals genes that are regulated in graft versus host disease. The major histocompatibility complex (MHC) is the most important genomic region that contributes to the genetic risk of graft rejection and graft versus host disease (GVHD) after haematopoietic stem cell transplantation. Therefore, MHC matching is most essential for the success of clinical transplantations. However, the MHC contains in addition to MHC class I and class II genes that are genotyped for selection of donors further so far unidentified genes that also contribute significantly to the risk to develop acute GVHD. It is difficult to identify these MHC genes by genetic association studies alone due to link

ORGANISM(S): Rattus norvegicus

SUBMITTER: Lennart Opitz 

PROVIDER: E-GEOD-17928 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress