Identification of differentially expressed genes in fibroblasts derived from patients with Dupuytren's Contracture

ABSTRACT: Dupuytren's contracture (DC) is the most common inherited connective tissue disease of humans and is hypothesized to be associated with aberrant wound healing of the palmar fascia. Fibroblasts and myofibroblasts are believed to play an important role in the genesis of DC and the fibroproliferation and contraction that are hallmarks of this disease. This study compares the gene expression profiles of fibroblasts isolated from DC patients and controls in an attempt to identify key genes whose regulation might be significantly altered in fibroblasts found within the palmar fascia of Dupuytren's patients. Total RNA isolated from diseased palmar fascia (DC) and normal palmar fascia (obtained during carpal tunnel release; 6 samples per group) was subjected to quantitative analyses using two diff

ORGANISM(S): Homo sapiens

SUBMITTER: Latha Satish 

PROVIDER: E-GEOD-21221 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress