Increased expression of Bcl11b in human transformed T cell lines leads to chemoresistance accompanied by G1 accumulation.

ABSTRACT: ABSTRACT Background: The expression of BCL11B has been reported in normal and transformed cells derived from T-lymphocytes, neurons, keratinocytes and recently in a subset of squamous cell carcinomas. Despite the rapidly accumulating knowledge concerning Bcl11b biology, the contribution of this protein to normal or transformed cell homeostasis remains open. Methodology/Principal Findings: Here, by employing an overexpression strategy and cells endogenously expressing BCL11B we revealed formerly unidentified features of Bcl11b which shed some light on the potential involvement of the protein in tumor maintenance. Two different T cell lines were forced to overexpress BCL11B which resulted in markedly increased resistance to radiomimetic drugs while no influence on death-receptor apoptotic pa

ORGANISM(S): Homo sapiens

SUBMITTER: Maren Depke 

PROVIDER: E-GEOD-21382 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress