Plasmodium falciparum W2/Dd2 Day 8 gametocytes

ABSTRACT: The sexual stages are vital phases in malaria parasite transmission and are the targets of various interventions such as transmission blocking vaccines. The molecular mechanisms underlying sexual development, however, remain poorly understood. We report mappping of a determinant previously linked to a male gametocyte development defect in the P. falciparum Dd2 parasite to an 82 kb region on chromosome 12. In order to find a critical gene in this region, we compared gene expression pattern in sexual stage of the parasite between Dd2 and its normal gametocyte-producing ancestor W2 clones. The region contains a sexual stage specific gene (pfmdv 1) that is expressed substantially at a lower level in the Dd2 than in W2 parasite. Disruption of pfmdv 1 results in a dramatic reduction in mature ga

ORGANISM(S): Plasmodium falciparum

SUBMITTER: Tetsuya Furuya 

PROVIDER: E-GEOD-2265 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress