Normal prostate cells were immortalized and cultured for 650 days till several transformation hallmarks were observed

ABSTRACT: Duplication of chromosomal arm 20q occurs in prostate, cervical, colon, gastric, bladder, melanoma, pancreas and breast cancer, suggesting that 20q amplification may play a key causal role in tumorigenesis. According to an alternative view, chromosomal instabilities are mainly a common side effect of cancer progression. To test whether a specific genomic aberration might serve as a cancer initiating event, we established an in vitro system that models the evolutionary process of early stages of prostate tumor formation; normal prostate cells were immortalized and cultured for 650 days till several transformation hallmarks were observed. Gene expression patterns were measured and chromosomal aberrations were monitored by spectral karyotype analysis at different times. Several chromosomal ab

ORGANISM(S): Homo sapiens

SUBMITTER: Yuval Tabach 

PROVIDER: E-GEOD-23038 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress