Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcriptional analysis of kidney infiltrating T cells after ischemia reperfusion injury reveals a pathophysiologic role for the chemokine (C-C motif) receptor 5

ABSTRACT: We examined the transcriptional responses in kidney infiltrating T cells 6 hrs after IRI CD3 (+) T cells were purified applying magnetic beads to mononuclear cells extracted from kidney by percoll gradient methods. The total T-cell RNA was isolated, and trabscript abundance measured with array-based PCR

ORGANISM(S): Mus musculus

SUBMITTER: Dmitry Grigoryev

PROVIDER: E-GEOD-23747 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptional analysis of infiltrating T cells in kidney ischemia-reperfusion injury reveals a pathophysiological role for CCR5.

Ko Gang Jee GJ Linfert Douglas D Jang Hye Ryoun HR Higbee Elizabeth E Watkins Tonya T Cheadle Chris C Liu Manchang M Racusen Lorraine L Grigoryev Dmitry N DN Rabb Hamid H

American journal of physiology. Renal physiology 20111207 6

Although T cells have been shown to play a direct role in kidney ischemia-reperfusion injury (IRI), little is known about the underlying mechanisms. We hypothesized that studying the transcriptional responses in kidney-infiltrating T cells would help elucidate novel therapeutic targets for kidney IRI. Unilateral renal pedicle clamping for 45 min was performed in male C57BL/6 mice, and CD3(+) T cells were isolated from the kidney and purified. Transcriptional activities of T cell were measured by ...[more]

PMID: 22160774

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Dataset Information

Transcriptional analysis of kidney infiltrating T cells after ischemia reperfusion injury reveals a pathophysiologic role for the chemokine (C-C motif) receptor 5

Publications

Transcriptional analysis of infiltrating T cells in kidney ischemia-reperfusion injury reveals a pathophysiological role for CCR5.

Similar Datasets

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