A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers

ABSTRACT: Specific changes in gene expression during cancer initiation should enable discovery of biomarkers for risk assessment, early detection and targets for chemoprevention. It has been previously demonstrated that altered mRNA and proteome signatures of morphologically normal cells bearing a single inherited “hit” in a tumor suppressor gene parallel many changes observed in the corresponding sporadic cancer. Here, we report on the global gene expression profile of morphologically normal, cultured primary breast epithelial and stromal cells from Li-Fraumeni syndrome (LFS) TP53 mutation carriers. Our analyses identified multiple changes in gene expression in both morphologically normal breast epithelial and stromal cells associated with TP53 haploinsufficiency, as well as interlocking pathwa

ORGANISM(S): Homo sapiens

SUBMITTER: Brittney-Shea Herbert 

PROVIDER: E-GEOD-23994 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress