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Effect on bone marrow mesenchymal stromal cells of mouse models of acute myeloid leukemia of different genotypes

ABSTRACT: We found that cells of acute myeloid leukemia (AML) affect the transcriptome of mesenchymal stromal cells (MSC) in bone marrow (BM) involved by AML. Gene expression in BM-MSC of AML-bearing mice differed from that in BM-MSC of control mice; some gene changes were the same across different types of AML produced by well-known fusion oncogenes, while others were specific to certain genotypes. There were notable differences between the effects of tp53 WT and tp53-/- AML with the same oncogene (MLL&FLT3-ITD); these were supported by in vitro experiments in which normal BM-derived MSC were cultured with the same tp53 WT and tp53-/- pair of AML cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE97194 | GEO | 2017/06/14

SECONDARY ACCESSION(S): PRJNA380934

REPOSITORIES: GEO

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Alkynyl nicotinamides with antileukemic activity to treat poor prognosis AM

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